泌尿器科領域における血清および尿中Tissue polypeptide antigen (TPA)の検討

Abstract

悪性腫瘍患者未治療群20例の血清TPAは, 健康者37例に比して有意に高値を示した.良性疾患患者未治療群との間には, 有意差は認められなかったが, 尿TPAは有意に高値を示した.前立腺癌および膀胱癌患者の多くで血清および尿TPAは治療により低下した.前立腺癌患者では血清TPAとPAP間に有意の相関関係が成立した.良性疾患では尿路感染症をもつ症例は, ない症例に比して血清および尿TPAが上昇した

We measured the serum and urinary TPA in 64 patients with urological cancer, 55 patients with benign urological disease and 37 healthy volunteers. The serum TPA levels in patients with pre-treated cancer were significantly higher than those of healthy volunteers, but showed no significant difference compared to those in patients with a benign urological disease. The urinary TPA levels in patients with pre-treated cancer were significantly higher than those with a benign urological disease, but in some patients with urinary tract infection, very high urinary TPA concentrations were observed. Therefore, the determination of serum and urinary TPA may be useful in detecting urological cancer, but they were not specific tests. On the other hand, as lower serum and urinary TPA levels were observed after treatment of bladder and prostatic cancer, their determinations were considered to be useful in following up patients with these cancers.