真菌性尿路感染症 - 第1報 -

Abstract

真菌性尿路感染症について患者背景およびその尿由来の真菌に対する5-FCのMICをBact-Yeast Morphology Agar培地を使用した希釈法により実施した.1)真菌性尿路感染症を有する患者背景としては留置カテーテル, 抗生物質, 合成抗菌剤の投与が密接に関係していた.2)尿中真菌分離頻度は115株中45株のC. albicansが最も多くついでC. tropicalis 25株, Trichosporon beigelli 22株であり, Torulopsis属は5株と最も少なかった.3) 60株(56%)は細菌と同時に分離されPseudomonas属, Streptococcus属との共存が多かった.4) Candida属, Torulopsis属にはおおむね良好なMICであったが, Candida属のなかではCandida tropicalisの60%が耐性であり, Trichosporon属では全てが50 μg/ml以上のMICであった

Clinical studies were performed on 115 fungal strains isolated from the urine of 36 patients. The predisposing factors were fungal urinary tract infections, antibiotics and indwelling catheter. Forty five strains of the 115 strains were Candida albicans, the most prevalent, followed by 25 strains of C. tropicalis and 22 strains of Trichosporon beigelii. Species of Torulopsis were rare, only 5 strains were isolated. Sixty strains (56%) co-existed with bacteria in urine. The co-existing bacteria most frequently isolated were Pseudomonas and Streptococcus. The minimum inhibitory concentration (MIC) of 5-FU was measured using the Bact-Morphology Agar medium. C. albicans, C. guillermondii, and Torulopsis glabrata showed an excellent MIC (under 0.78 microgram/ml), C. tropicalis, C. parapsilosis, T. beigelii, and T. cutaneum showed a poor MIC (over 100 micrograms/ml).