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Title: 膀胱癌の抗癌剤感受性試験 -- ヌードマウス実験系による--
Other Titles: Chemosensitivity test for bladder cancer in a nude-mice experimental system
Authors: 山内, 民男  KAKEN_name
岡田, 謙一郎  KAKEN_name
吉田, 修  KAKEN_name
河合, 恒雄  KAKEN_name
Author's alias: YAMAUCHI, Tamio
OKADA, Kenichirou
YOSHIDA, Osamu
KAWAI, Tuneo
Keywords: Chemosensitivity test
Bladder cancer
Nude mice
Subrenal capsule assay
Issue Date: Dec-1986
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 32
Issue: 12
Start page: 1949
End page: 1958
Abstract: The in vivo chemosensitivity test for bladder cancer, using the human bladder cancer xenografts (BT-8 and BT-11 strains) in nude mice (BALB/c) and the BBN-BT-1 bladder cancer strain in BALB/c hetero-mouse which was induced by peroral long-period administration of N-butyl-N-(4-hydroxybutyl) nitrosamine and transplantable into the subcutaneous of mouse, were examined especially in respect to the difference of chemosensitivity between young and old straining and the prospective propriety for clinical application. The subrenal capsule assay (SRC), was also compared with subcutaneous transplantation. Cis-diamminedichloroplatinum (II) and 5-FU were effective for all three strains and adriamycin and cyclophosphamide were effective for the BT-8 and BT-11 strains. Bleomycin, peplomycin and vinca alkaloids were more effective for the BT-11 strain than the BT-8 strain. The chemosensitivity of several anti-cancer drugs for the young BT-8 and BT-11 strains was almost equal to that of the old. A 68-year-old male with bladder cancer metastasized to lung and lymph nodes, whose primary tumor was transplanted to mice and established as the BT-11 strain in 1980, was treated with the VPM-CisCF combination chemotherapy which was evaluated as an effective therapy for this strain experimentally, and responded well to this therapy. As in this case, the results of nude mice experiments are valuable in clinical application. The chemosensitivity test in vivo for individual primary tumors should be done by SRC, and in SRC nude mice should be used instead of conventional mice until immunoreactive rejection can be prevented.
URI: http://hdl.handle.net/2433/118978
PubMed ID: 3825832
Appears in Collections:Vol.32 No.12

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