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32_1941.pdf | 2.04 MB | Adobe PDF | 見る/開く |
タイトル: | 膀胱腫瘍の光力学的レーザー治療 |
その他のタイトル: | Photodynamic therapy of superficial bladder tumors |
著者: | 三崎, 俊光 久住, 治男 平田, 昭夫 国見, 一人 山本, 肇 天野, 俊康 熊木, 修 越田, 潔 西野, 昭夫 中嶋, 和喜 打林, 忠雄 内藤, 克輔 |
著者名の別形: | MISAKI, Toshimitsu HISAZUMI, Haruo HIRATA, Akio KUNIMI, Kazuto YAMAMOTO, Hazime AMANO, Toshiyasu KUMAKI, Osamu KOSHIDA, Kiyoshi NISHINO, Akio NAKAZIMA, Kazuyoshi UCHIBAYASHI, Tadao NAITO, Katsusuke |
キーワード: | Bladder tumor Hematoporphyrin derivative Argon-dye laser Photodynamic therapy |
発行日: | Dec-1986 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 32 |
号: | 12 |
開始ページ: | 1941 |
終了ページ: | 1948 |
抄録: | Photodynamic therapy (PDT), using hematoporphyrin derivative (HPD) and the red light (wavelength 630 nm) of an argon-dye laser as the source of excitation energy was performed on 46 patients with superficial bladder tumors. Two methods of laser irradiation, (1) focal PDT using a 400 micron quartz fiber through a cystourethroscope in 22 patients with superficial bladder tumors and (2) whole bladder wall total PDT using a motor-driven laser light scattering device in 24 patients with multifocal carcinoma in situ and/or dysplasia of bladder mucosa associated with multicentric concurrent superficial tumors, were used. The patients in (2) had been referred for total cystectomy, and 19 of these 24 patients had a history of several transurethral resections, hyperthermia and/or instillation therapy. HPD 2-4 mg/kg was i.v. injected 48 to 72 hours before PDT. Judging from the results of 60 protrusions treated by focal PDT, the light power should be 200 mW/cm2 for 5-10 minutes or more and the total light energy should be 100 J/cm2 or more in tumors up to 2 cm in size. With focal PDT, 4 of the 22 patients had no recurrence with the mean tumor free time of 20.8 months. In 6 of the 24 patients treated with total PDT using 10, 20 or 30 J/cm2 of light energy, there was no recurrence with a mean tumor-free time of 7.5 months and there was no significant relationship between the recurrence rate and total light energy used. |
URI: | http://hdl.handle.net/2433/118979 |
PubMed ID: | 3825831 |
出現コレクション: | Vol.32 No.12 |
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