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|Title:||尿路結石再発に関する臨床的検討 (1)結石構成物質の尿中排泄について : 特に入院普通食下と外来自由食下の差について|
|Other Titles:||Clinical studies on the recurrence of urolithiasis: (1). Influence of diet on urinary excretion of the stone forming constituents|
|Authors:||村山, 鉄郎 |
|Author's alias:||MURAYAMA, Tetsuo|
|Keywords:||Recurrence of urolithiasis|
Stone forming constituents in urine
|Abstract:||尿路結石の再発防止法を検討するために,尿中Ca,尿酸,蓚酸,P, Mg排泄を一定の内容を有する入院普通食下と個々の内容の異なる外来自由食下で測定した.1)入院食下にくらべ外来食下では男子結石例で尿中Ca,尿酸,Mg排泄量が有意に増加し,女子結石例ではCa, Mg排泄が有意に増加した.2)結石例と非結石例の尿中Ca,尿酸,蓚酸,P排泄量は入院食下でも外来食下でも差はみられなかった.しかし,結石例の尿中Mg排泄は入院食下では非結石例にくらべて有意に低く,結石例におけるMg排泄障害の存在が示唆された.しかし,外来食下では結石例と非結石例で尿中Mg排泄量に差はみられなかった.3)結石例を初発で片側性のものと,初発でも両側性のもの及び再発性のものの2群にわけ,尿中Ca,尿酸,蓚酸,P, Mg排泄量を比較すると,入院食下でも外来食下でも両群間に差は認められなかった|
Twenty-four hour urinary excretion of the stone forming constituents, calcium, oxalate, uric acid, phosphate and magnesium were assayed either under the restricted diet (190 stone formers and 52 non-stone formers) or under the ambulatory free diet (93 stone formers and 14 non-stone formers). Under the ambulatory free diet, urinary excretion of calcium, uric acid and magnesium in the male stone formers, and urinary excretion of calcium and magnesium in the female stone formers was significantly higher than that under the restricted diet. Under the restricted diet, no difference in urinary excretion of calcium, oxalate, uric acid or phosphate was noted between the stone formers and non-stone formers. However, urinary magnesium excretion of the stone formers under the restricted diet was significantly lower than that of the non-stone formers. Under the free diet, no difference in urinary excretion of calcium, oxalate, uric acid, phosphate or magnesium was observed between the stone formers and non-stone formers. Also, there was no significant difference in urinary excretion of calcium, oxalate, uric acid, phosphate or magnesium between the unilateral urolithiasis patients without previous stone history and that of the bilateral or recurrent stone formers. We conclude that urinary excretion of calcium, oxalate, uric acid, phosphate and magnesium have no major role in the stone producing mechanism. However, reduction of urinary excretion of calcium, oxalate, uric acid and phosphate and augmentation of urinary excretion of magnesium are mandatory in preventing stone recurrence until a better understanding of the cause of urolithiasis is obtained.
|Appears in Collections:||Vol.33 No.9|
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