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タイトル: | 男子尿道炎患者から分離されたpenicillinase-producing Neisseriagonorrhoeae (PPNG) について |
その他のタイトル: | Detection of penicillinase-producing Neisseria gonorrhoeae from male patients with urethritis |
著者: | 大川, 光央 中嶋, 孝夫 徳永, 周二 川口, 正一 菅田, 敏明 久住, 治男 上野, 一恵 渡辺, 邦友 |
著者名の別形: | OHKAWA, Mitsuo NAKAJIMA, Takao TOKUNAGA, Shuji KAWAGUCHI, Shoichi SUGATA, Toshiaki HISAZUMI, Haruo UENO, Kazue WATANABE, Kunitomo |
キーワード: | Male urethritis Penicillinase-producing Neisseria gonorrhoeae (PPNG) Susceptibility of antimicrobial agents |
発行日: | Jan-1988 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 34 |
号: | 1 |
開始ページ: | 130 |
終了ページ: | 136 |
抄録: | 1985年に受診した男子GU患者89例の尿道smearから分離された淋菌89株中12株がPPNGと判定され, これらPPNGはPCG, AMPCに高度耐性を示し, CTXのMICが最も低値を示した.また, 89例中60例にC. trachomatisの検索を施行し, 11例が陽性であった Eighty-nine isolates of Neisseria gonorrhoeae from 89 male urethritis patients were studied for beta-lactamases (penicillinase) production, and their susceptibilities to benzylpenicillin, amoxicillin, piperacillin, clavulanic acid/amoxicillin (Augmentin), cephalexin, cefotaxime, spectinomycin and minocycline were determined by an agar plate-dilution method. Penicillinase activity was tested by a chromogenic cephalosporin method with nitrocefin as substrate (CefinaseTM discs, BBL, USA) and by a paper strip acidimetric method with benzylpenicillin as substrate (beta-Lactamase detection papers, Oxoid, UK). In addition, 60 of the 89 patients were examined for Chlamydia trachomatis, using fluorescein-labeled monoclonal antibodies (Direct specimen test; Micro TrakTM, Syva Co., USA). Penicillinase-producing N. gonorrhoeae (PPNG) were found in 12 of the 89 strains (13.5%). Although all these strains of PPNG were highly resistant to benzylpenicillin and amoxicillin, the minimum inhibitory concentrations (MICs) of Augmentin markedly decreased. Piperacillin was highly active against not only non-PPNG but also PPNG strains. More than half the isolates were resistant to cephalexin (MICs greater than or equal to 12.5 micrograms/ml) while all strains including non-PPNG and PPNG were fully sensitive to cefotaxime (MICs less than or equal to 0.20 microgram/ml). Spectinomycin and minocycline had MIC ranges of 6.25 to 25 micrograms/ml and 0.01 to 3.13 micrograms/ml, respectively; the ranges for non-PPNG and PPNG strains were fairly similar. C. trachomatis was detected in 11 (18.3%) out of 60 patients examined. The increasing incidence of PPNG and coexisting chlamydial infection should be taken into account in the treatment of gonococcal urethritis. |
URI: | http://hdl.handle.net/2433/119422 |
PubMed ID: | 3132029 |
出現コレクション: | Vol.34 No.1 |
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