エノキサシン3日間連続投与後の前立腺組織内濃度について

Abstract

前立腺肥大症患者35例に対してエノキサシン1日600 mgを3日間経口投与し, 2 groupに分けて前立腺組織内濃度(P)および血清中の濃度(S)を測定した.200 mg最終投与後約17時間を経過したgroupにおいてPは1.87±1.23 μg/gで, Sは1.05±0.458 μg/mlであり, 5.5時間を経過したgroupではPは2.51±0.725 μg/gで, Sは1.78±0.586 μg/mlであった.またP/Sはそれぞれ1.75±0.678および1.46±0.385で, 1例を除いて1以上であり, 血清よりも前立腺組織内により高濃度に残留していた.また前立腺組織内濃度は大多数の菌種のMICと同等あるいはそれ以上の濃度であるため, 前立腺炎などに対して十分に期待できる薬剤であると思われた

The penetration of enoxacin into prostatic tissue was examined Thirty-five patients with benign prostatic hypertrophy entered the study. Enoxacin was administered orally in a dose of 200 mg three times daily for 3 days preoperatively. Blood samples were taken simultaneously at the time of tissue sampling. The patients were divided into groups 1 and 2. In group 1, tissue sampling was done after about 17 hours of final administration of the drug. The mean concentration of enoxacin in prostatic tissue was 1.87 +/- 1.23 micrograms/g and 1.05 +/- 0.458 micrograms/ml in serum. In group 2, sampling was done after 5.5 hours of final administration. The mean concentration of enoxacin in prostatic tissue was 2.51 +/- 0.725 micrograms/g and 1.78 +/- 0.586 micrograms/ml in serum.