尿路結石再発に関する臨床的検討 (3) Na摂取と尿中Ca,尿酸,蔭酸,P, Mg排泄について

Abstract

尿路結石患者の尿中Na排泄量と尿中Ca, 尿酸, PおよびMg排泄量との間には男女ともそれぞれ有意の正の相関関係が認められた.尿中Naと蓚酸排泄量との間では男子で有意の正の相関が認められたが, 女子では認められなかった.3日間の減塩食により尿中Na排泄は著しく減少した.これに伴って, 尿中Ca, 尿酸, 蓚酸排泄も有意に減少した.しかし, 尿中PおよびMg排泄は変動がなく, 尿中クレアチニン排泄も不変であった

Relationship between urinary sodium excretion and urinary excretion of calcium, uric acid, oxalate, phosphate and magnesium was analyzed in 93 ambulatory patients with urolithiasis. There was a significant correlationship between urinary sodium excretion and urinary excretion of calcium, uric acid, oxalate (only in male stone formers), phosphate and magnesium, respectively. Under a salt restricted diet (NaCl 3-5 gm/day) for 3 days, urinary sodium excretion of 16 inpatients with urolithiasis was reduced remarkably together with significant reduction of urinary excretion of calcium, uric acid and oxalate. Urinary excretion of phosphate and magnesium showed no change. From these findings we conclude that restriction of sodium intake is an effective treatment for prevention of stone recurrence.