ヒト精巣機能に及ぼす高温環境の影響

Abstract

8例の無治療前立腺癌患者の精巣を用い, 33°Cおよび37°Cで7日間器官培養した際の精巣組織125I-hCG bindings, 125I-FSH bindingsおよび培養液で遊出されるtestosterone濃度を両群間で比較した.1) 33°Cで培養した群と37°Cで培養した群間で精巣組織125I-hCG bindings, 125I-FSH bindingsおよび培養液中testosterone濃度はいずれも有意差を認めなかった.2)以上の結果より, 短期間の精巣器官培養においてはヒト精巣Leydig cellおよびSertoli cell機能は障害されない

The influence of temperature on human Leydig and Sertoli cell functions was investigated in vitro using the organ culture technique. Specific 125I-FSH and 125I-hCG binding sites in testes from patients with prostate cancer cultured for 1, 3, 5 or 7 days at 33 degrees C or 37 degrees C were measured and compared. There were no significant differences in 125I-FSH or 125I-hCG binding sites between the two temperature groups at 1 to 7 days of culture. Testosterone concentration in the medium obtained from testicular organ culture at 33 degrees C did not differ significantly from that at 37 degrees C at 1 to 7 days of culture. In conclusion, a high temperature may not disturb the Leydig and Sertoli cell functions in a short term.