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dc.contributor.author | 岡村, 武彦 | ja |
dc.contributor.alternative | OKAMURA, Takehiko | en |
dc.date.accessioned | 2010-06-02T02:58:35Z | - |
dc.date.available | 2010-06-02T02:58:35Z | - |
dc.date.issued | 1988-11 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/119782 | - |
dc.description.abstract | 1) mitomycin Cやcis-dichlorodiamine platinumの膀注は, 完成されたラット膀胱癌に対して治療効果を発揮した.2)しかし, adriamycinやMMCは前癌変化から膀胱癌発生の顕性化を促進した | ja |
dc.description.abstract | After administration of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) to 6-week-old, female F344 rats, various anticancer agents and immunotherapeutic agents were injected into the bladder and their effects were investigated. Injection of adriamycin and mitomycin C (MMC) into the bladder a total of 12 times, 4 weeks after administration of BBN markedly promoted carcinogenesis of the bladder. Injection of bleomycin, cis-dichlorodiamine platinum (CDDP) and picibanil into the bladder a total of 12 times, 4 weeks after administration of BBN did not promote carcinogenesis and CDDP exhibited a tendency to inhibit carcinogenesis. Injection of MMC, CA (cytarabine) and MMC + CA into the bladder a total of 12 times, 4 weeks after administration of BBN indicated that CA has the potential to inhibit the bladder carcinogenesis-promoting effect of MMC. Injection of CDDP and MMC into the bladder a total of 12 times, 20 weeks after administration of BBN inhibited proliferation of bladder carcinoma. Additionally, administration each of CDDP and MMC alone exhibited a carcinogenic effect on the bladder. The above-described results show that considerable care should be taken and that long-term observation of course is required with the use of anticancer agents such as ADM and MMC. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.subject | Bladder carcinogenesis | en |
dc.subject | Intrabladder instillation | en |
dc.subject.ndc | 494.9 | - |
dc.title | ラット膀胱発癌における各種抗癌剤膀胱内注入の影響 | ja |
dc.title.alternative | Effect of intrabladder instillation of various anticancer agents on carcinogenesis in rat bladder | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 1895 | - |
dc.identifier.epage | 1902 | - |
dc.textversion | publisher | - |
dc.sortkey | 05 | - |
dc.address | 名古屋市立大学医学部泌尿器科学教室 | ja |
dc.address.alternative | the Department of Urology, Medical School, Nagoya City University | en |
dc.identifier.pmid | 3149447 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.34 No.11 |
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