睾丸腫瘍の化学療法に関する研究 第1編: Nitrofurazoneの睾丸腫瘍におよぼす影響について

Abstract

As in malignant neoplasms general, chemotherapy of testicular tumor intends to radical cure of the focus, for which improvement of operative and irradiation treatments have intensively attempted. Observation at necropsy of the cases of testicular tumors, however, reveals that original tumor metastasized to the lung and liver in approximately a half of cases despite powerful treatments. Development of chemotherapeutic agents which are capable of generally administered is necessary to achieve the purpose of treatment. Since the majority of testicular tumors is originated from the germinal cell, one of the valid approach for chemotherapy of testicular tumor is to develop medical agents which have marked affinity to the germinal cell with large chemotherapeutic index to somatic cells. On the points of view, studies were performed on several chemical agents in relation to experimental and clinical evidences of their effects. This report deals with the effect of nitrofurazone, one of the antispermatogenic drugs, to the testicular tumors. Based on the toxic effect of this drug to germinal cell, Friedgood reported in 1952 that the drug is useful for treatment of human testicular tumor. However on our 14 patients with testicular tumor and on heterotransplanted tumor cell, the results of administration of the drug showed no significant difference between the treated and control groups.