尿路感染症の薬剤耐性とNalidixic Acidの治験について

Abstract

A total of 282 organisms isolated during the year of 1966 from ambulatory patients with urinary tract infection at the Anjoh Kosei Hospital, Anjoh, were examined for percentage frequency of isolation as well as percentage resistance to a series of eight antibiotics by the bacterial species, for degree of their pathogenicity to urinary tract infection, and for the presence of multiple resistance to antibiotics, For inhibition of the growth of E. coli in vitro, the most effective agents were Nalidixic acid and PanfuranS followed, in order, by kanamycin, cephaloridine, colimycin, streptomycin, chloramphenicol and tetracycline, A clinical trial with the narrow-spectrum antibacterial agent Wintomylon (nalidixic acid) which thus showed the lowest MIC values against E. coli was conducted in a series of 124 patients with urinary tract infection, and the results obtained confirmed its potential usefulness in this disease state.