実験的低血圧と腎機能に関する研究 第2編: Hexamethonium(C6)負荷による低血圧と腎機能の変動について

Abstract

Split renal function studies were carried out on thirty-two urologic patients with emphasis on the changes of renal functions under hexamethonium (C6) loading. For such a purpose, PAHclearance, STS-clearance, urinary out-put, specific gravity, pH, sodium and potassium concentration were determined. 1) In both of normotensive and hypertensive group, C6-induced hypotension caused diminution of urine out-put from healthy and diseased kidneys. 2) In normotension and essential hypertension group, C6-induced low blood pressure caused slight decrease of PAH-clearance, STS-clearance and urinary sodium as well as slight increase of urinary potassium concentration if it was above 80 mmHg in mean pressure. In the cases in which mean pressure was lowered below 80 mmHg, the changes were greater especially on the healthy kidneys. In renal hypertension, the rate of changes varied in accordance with the grade of preexisting functional impairment of the kidney. Even under a mean pressure of 120 mmHg induced by C6 administration, the changes were striking in some of the cases. In such condition, relative hypotension must be always kept in mind to evaluate renal function. 3) Urine specific gravity and pH showed no change or slight decrease in b o th of hypertensive and normotensive group.