二重盲検法によるPentazocineの泌尿器科手術後疼痛に対する効果の検討

Abstract

Pentazocine was studied by means of a double-blind clinical investigation in 50 patients postoperatively. Thirty milligram pentazocine was given intramuscularly to each patient when he complained severe pain, and clinical effects were evaluated. 1) Twenty-three patients were put on pentazocine and 27 patients on placebo. Both groups were composed with similar patients in age distribution and severity of operative suffering. 2) Pain relief was excellent in 21 and good in 2 of 23 patients on pentazocine, while good in 10 and poor in 17 of 27 patients on placebo. 3) Drowsiness were observed in 32 of 50 patients, 21 of pentazocine-treated group and 11 of placebo-treated group. Sweating (5 cases), euphoria (3 cases), nausea (3 cases), pain of injection site (2 cases) and dizziness (1 case) were observed only in pentazocine-treated group.