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タイトル: 精索静脈瘤に対するParaphlebonの効果
その他のタイトル: Effect of paraphlebon on varicocele
著者: 水本, 竜助  KAKEN_name
鈴木, 良徳  KAKEN_name
著者名の別形: Mizumoto, Ryusuke
Suzuki, Ryotoku
キーワード: Adolescent
Adult
Child
Humans
Infertility, Male/drug therapy/etiology
Male
Middle Aged
Spermatozoa
Varicocele/drug therapy
発行日: Jan-1970
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 16
号: 1
開始ページ: 37
終了ページ: 44
抄録: It is now well known that varicocele often causes male infertility and its operative treatment is indicated. However, drug therapy of varicocele has not been investigated. Paraphlebon, an effective drug on varicose vein, was clinically tried for treatment of male infertility due to varicocele. Through this study, mechanism of ill effect of varicocele on spermatogenesis was investigated. Paraphlebon was orally administered to eighty-five patients 'with varicocele for three weeks to three months. The following results were obtained. 1. Varicocele disappeared or remarkably regressed in twenty-nine patients. The rest of the patients showed some regression. 2. Sperm count increased in 70 of 79 patients. 3. Sperm motility increased in 72 of 79 patients. 4. Testicular histology before the treatment was normal in 21 of 43 biopsies. But it was normal in 30 after the treatment. 5. Out of 34 infertile males, 9 had pregnancy within one year after the treatment. The clinical results of Paraphlebon, seem to be as good as operative treatment. It was not elucidated why the unilateral varicocele affects spermatogenesis of the other side. Since spermatogenesis has improved by the drug therapy, long-standing ischemia of the testis seems to exert hypospermatogenesis of the contralateral testis. This hypofunction may be reversible to some extent.
URI: http://hdl.handle.net/2433/121081
PubMed ID: 5461371
出現コレクション:Vol.16 No.1

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