シンチカメラによる研究 "197Hg-クロルメロドリンによる腎シンチグラフィーの検討"

Abstract

The [203]Hg-labelled Chlormerodrin has been mainly used for kidney scintigraphy. However, [197]Hg-labelled Chlormerodrin has the possibilities of repeated examinations and application to pediatrics because [197]Hg has shorter half-life and less radiation exposure to patients than [203]Hg. Here fundamental and clinical investigation on [197]Hg-Chlormerodrin for kidney scanning agent was performed with an idea that this scanning agent will be widely used in place of [203]Hg. Chlormerodrin in the near future. Total 20 cases were examined using [197]Hg-Chlormerodrin and these results were compared with those of [203]Hg-Chlormerodrin. There were some differences in conditions of taking the scintigrams, but no differences on obtained scintigrams were recognized. The most suitable time period for taking the scintigrams with [197]Hg-Chlormerodrin was 3 to 24 hours after the intravenous administration. The remaining radioactivity of [197]Hg-Chlormerodrin in kidney 10 days after the intravenous administration was not observed because of its short physical halflife of 2.7 days and excretion in urine. The radioactivities of [197]Hg-Chlormerodrin in the urine decreased as 100: 10 : 1 = in the first 24 hours: the second 24 hrs. : the third 24 hrs. No radioactivity was recognized after the third day.