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Title: 膀胱癌再発防止法としてのthio-TEPAとurokinaseの併用膀胱内注入療法
Other Titles: THE PROPHYLACTIC USE OF THIO-TEPA AND UROKINASE IN TRANSITIONAL CELL, CARCINOMA OF THE BLADDER
Authors: 久住, 治男  KAKEN_name
打林, 忠雄  KAKEN_name
内藤, 克輔  KAKEN_name
三崎, 俊光  KAKEN_name
宮崎, 公臣  KAKEN_name
黒田, 恭一  KAKEN_name
Author's alias: Hisazumi, Haruo
Uchibayashi, Tadao
Naito, Katsusuke
Misaki, Toshimitsu
Miyazaki, Kimiomi
Kuroda, Kyoichi
Issue Date: Aug-1975
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 21
Issue: 8
Start page: 735
End page: 742
Abstract: The prevention of recurrences of bladder cancer was attempted in 80 patients (33 patients of our department and 47 patients of affiliated hospitals in the Hokuriku area) by means of the combined intravesical instillation of thio-TEPA and urokinase and in 28 patients of our department by the instillation of thio-TEPA alone. The recurrence rates of both therapies for the postoperative 36 months were 7.3 and 32.6 per cent in patients in our department, respectively, indicating a significant drop in the recurrence rate in the group subjected to the combined therapy. The recurrence rate of the group of 80 patients was 18.5 per cent. Leucopenia was found in 17 of 80 patients receiving the combined instillation therapy. However, this was not attributable to the use of urokinase. To clarify the mechanism involved in the action of urokinase in combined therapy, further physio-pathological and biochemical studies as well as long-term clinical follow-up studies are needed.
URI: http://hdl.handle.net/2433/121865
Appears in Collections:Vol.21 No.8

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