尿路性器感染症患者尿中分離菌の薬剤感受性の最近の動向

Abstract

Minimum inhibitory concentration (MIC) of 9 chemotherapeutic drugs (T-I220, carbenicillin, sulbenicillin, ampicillin, cephaloridine, cephalothin, cefazolin, gentamicin, dibekacin) to 123 organisms isolated from urine was investigated in 33 patients (66 complicated urinary tract infections, 11 simple urinary tract infections, 11 infections of male genital organs) during the period from March 1976 to August 1976. 1) The organisms isolated consisted of E. coli (27 strains), Pseudomonas aeruginosa (24 strains), Proteus spp. (23 strains), Serratia marcescens (13 strains), Klebsiella (11 strains), Streptococcus faecalis (5 strains), Citrobactor (5 strains), Enterobacter (4 strains) and others (11 strains). 2) The results of MIC distributions were as follows: a) E. coli: E. coli might be clearly divided into two groups, sensitive and resistant, to semisynthetic penicillin derivatives (T-1220, carbenicillin, sulbenicillin, ampicillin). And it was noted that 10 of 14 strains with MIC of 200 µg/ml or higher (inoculum size 106 cells/ml) for carbenicillin, sulbenicillin and ampicillin were isolated from the patients with complicated urinary tract infections. b) Pseudomonas aeruginosa: T-1220, gentamicin and dibekacin were petent antimicrobial agents against Pseudomonas aeruginosa. But it was noted that 9 strains with MIC of 12.5 µg/ml or higher (inoculum size 10[6] cells/ml) for gentamicin were isolated. c) Proteus spp.: Proteus spp. was generally resistant to the drugs tested in this investigation. And it was noted that 7 strains with MIG of 25 f-µg/ml or higher (inoculum size 10[6] cells/ml) for gentamicin were isolated. d) Serratia marcescens: Serratia marcescens was generally resistant to the drugs tested except gentamicin. e) Klebsiella: Gentamicin and dibekacin were generally potent against Klebsiella..