多発性・再発性膀胱腫瘍に対する抗腫瘍剤膀胱内注入療法

Abstract

Intravesical instillations of 250 mg 5-fluorouracil, 5 mg carboquone and 200 mg cytosine arabinoside in 30 ml of saline were employed in 20 patients with multiple and recurrent superficial bladder tumor which were less than the small finger tip in size. This instillation was carried out once a week and the instillation of five weeks duration was one course of this treatment. After one to three courses of instillation, complete destructions were found in all tumors except ones lying in bladder neck and around or at ureteral orifice. Complete disappearance of tumor was found in all of 20 cases except specially located tumor as above mentioned. Bladder irritability was complained in 5 cases and hemorrhagic cystitis developed in 2 cases, but these side effects subsided after the short term cessation of treatment allowing to continue instillation. White blood cell and platelet count during treatment showed a tendency of depression in a few cases but did not drop to abnormal range. Intravesical instillation of the three anticancer drugs showed an excellent effect for the purpose of destruction of small multiple bladder tumor and perhaps of invisible tumor with the endoscopic eye. The treatment may also be useful in diminishing the recurrence rate of tumor.