KES-504(Estracyt)による前立腺癌の組織学的変化について --前立腺全摘除術施行前投与の1例--

Abstract

A 46-year old man complaining of asymptomatic macroscopic hematuria was diagnosed as poorly differentiated adenocarcinoma by transrectal needle biopsy. Oral estramustine phosphate had been administered in doses of 560 mg/day for 6 weeks before the total prostatectomy was performed. The histologic examination revealed that the tumor had changed into the necrosis completely, although a few cancer cells with cytolytic change were observed. Surrounding the necrotic area, there are numbers ofhistiocytes and giant cells combined with the loose fibrous connective tissue which means the demarcation of the tumor areas. On the other hand, dilatations of the acinal spaces, decrease of height of the epithelial cells and stromal fibrosis were observed in the normal prostatic tissues. Judging from these figures, Estracyt has not only an estrogenic effect on the prostate but a cytotoxic effect on the prostatic cancer cells. The literatures regarding the hormone therapy of prostatic cancer and the influences on the prostatic cancer cells caused by antiandrogen therapy were reviewed briefly.