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Title: PC-904の慢性尿路感染症に対する臨床的検討
Authors: 郡, 健二郎  KAKEN_name
永井, 信夫  KAKEN_name
松浦, 健  KAKEN_name
金子, 茂男  KAKEN_name
井口, 正典  KAKEN_name
南, 光二  KAKEN_name
門脇, 照雄  KAKEN_name
秋山, 隆弘  KAKEN_name
八竹, 直  KAKEN_name
栗田, 孝  KAKEN_name
吉田, 真弓  KAKEN_name
吾郷, 民恵  KAKEN_name
田中, 美智男  KAKEN_name
大場, 康寛  KAKEN_name
Author's alias: Kohri, Kenjiro
Nagai, Nobuo
Matsuura, Takeshi
Kaneko, Shigeo
Iguchi, Masanori
Minami, Kohji
Kadowaki, Teruo
Akiyama, Takahiro
Yachiku, Sunao
Kurita, Takashi
Yoshida, Mayumi
Ago, Tamie
Tanaka, Michio
Oba, Yasuhiro
Issue Date: Oct-1978
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 24
Issue: 10
Start page: 899
End page: 904
Abstract: Clinical studies on PC-904, a new broad spectrum semisynthetic penicillin with high antipseudomonas activity, were carried out as follows. PC-904 was administered to 20 cases of chronic urinary tract infections with drip infusion at the dosage of 1 to 4 g twice a day for a period of 4 to 8 days. Clinical effects were evaluated with "criteria for clinical evaluation of antimicrobial agents on U. T. I.". Clinical efficacy rate was 20% in small dosage group (1 g/time), 60% in large dosage group (more than 2 g/time), and totally 40%. In these cases, PC-904 was effective for the cases to resist against other various antibiotic therapies. But it was not effective to patients with an indwelling catheter or low vital activities. As to the relation between the MIC and the efficacy, it seems to be more effective to be treated with more than 2 g of the PC-904. No significant adverse reaction was noted, but transient elevations of GOT or GPT were observed in 2 cases.
Appears in Collections:Vol.24 No.10

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