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タイトル: 緑膿菌および変形菌による慢性尿路感染症に対するFosfomycin NaとSulbenicillin Naの薬効比較試験
その他のタイトル: COMPARISON OF CLINICAL EFFECTS OF FOSFOMYCIN NA AND SULBENICILLIN NA IN CHRONIC URINARY TRACT INFECTIONS
著者: 佐藤, 昭太郎  KAKEN_name
狩野, 健一  KAKEN_name
中野, 欣也  KAKEN_name
渡辺, 悌三  KAKEN_name
浜路, 政博  KAKEN_name
阿部, 禮男  KAKEN_name
姉崎, 衛  KAKEN_name
峰山, 浩忠  KAKEN_name
小林, 良彦  KAKEN_name
中村, 章  KAKEN_name
安食, 悟朗  KAKEN_name
河路, 清  KAKEN_name
斉藤, 良司  KAKEN_name
武田, 正雄  KAKEN_name
高野, 崇  KAKEN_name
千葉, 栄一  KAKEN_name
高島, 彰夫  KAKEN_name
桜井, 叢人  KAKEN_name
関根, 昭一  KAKEN_name
金子, 佳雄  KAKEN_name
志賀, 弘司  KAKEN_name
著者名の別形: Sato, Shotaro
Kano, Kenichi
Nakano, Kinya
Watanabe, Teizo
Hamaji, Masahiro
Abe, Norio
Anezaki, Mamoru
Mineyama, Hirotada
Kobayashi, Yoshihiko
Nakamura, Sho
Ajiki, Goro
Kawaji, Kiyoshi
Saito, Ryoji
Takeda, Masao
Takano, Mitsuru
Chiba, Eiichi
Takashima, Akio
Sakurai, Shigeto
Sekine, Shoichi
Kaneko, Yoshio
Shiga, Koji
発行日: Jan-1979
出版者: 京都大学医学部泌尿器科学教室
誌名: 泌尿器科紀要
巻: 25
号: 1
開始ページ: 87
終了ページ: 102
抄録: In order to determine clinical effect of fosfomycin Na(FOM) in urinary tract infections caused by Pseudomonas and Proteus, a comparative study was carried out on patients with chronic complicated urinary tract infections, using sulbenicillin Na(SB-PC) as an active control drug. Both FOM and SB-PC were administered through intravenous infusions in the same dosage of 2 g twice daily for a period of 5 days, and comparisons were made in terms of clinical and bacteriological effects and adverse reactions with a single blind technique. The results obtained were as follows: 1. There was no significant difference in global clinical effects between FOM and SB-PC. 2. With respect to clinical effects as classified by the types of disease, FOM was found to be superior with significant difference in the group of low urinary tract infection. 3. Determinations of MICs of FOM and SB-PC for the isolated organisms revealed higher sensitivity of FOM with significant difference, although no statistically significant difference was seen in terms of disappearance of bacteriuria between the two drugs. 4. There was no significant difference in frequencies of adverse reactions between FOM and SB-PC. All the observed reactions were mild in nature and occurred only in a small number of cases. Therefore, it was concluded that both drugs are of sufficient value to be applied clinically.
URI: http://hdl.handle.net/2433/122363
出現コレクション:Vol.25 No.1

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