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25_0087.pdf | 1 MB | Adobe PDF | 見る/開く |
タイトル: | 緑膿菌および変形菌による慢性尿路感染症に対するFosfomycin NaとSulbenicillin Naの薬効比較試験 |
その他のタイトル: | COMPARISON OF CLINICAL EFFECTS OF FOSFOMYCIN NA AND SULBENICILLIN NA IN CHRONIC URINARY TRACT INFECTIONS |
著者: | 佐藤, 昭太郎 狩野, 健一 中野, 欣也 渡辺, 悌三 浜路, 政博 阿部, 禮男 姉崎, 衛 峰山, 浩忠 小林, 良彦 中村, 章 安食, 悟朗 河路, 清 斉藤, 良司 武田, 正雄 高野, 崇 千葉, 栄一 高島, 彰夫 桜井, 叢人 関根, 昭一 金子, 佳雄 志賀, 弘司 |
著者名の別形: | Sato, Shotaro Kano, Kenichi Nakano, Kinya Watanabe, Teizo Hamaji, Masahiro Abe, Norio Anezaki, Mamoru Mineyama, Hirotada Kobayashi, Yoshihiko Nakamura, Sho Ajiki, Goro Kawaji, Kiyoshi Saito, Ryoji Takeda, Masao Takano, Mitsuru Chiba, Eiichi Takashima, Akio Sakurai, Shigeto Sekine, Shoichi Kaneko, Yoshio Shiga, Koji |
発行日: | Jan-1979 |
出版者: | 京都大学医学部泌尿器科学教室 |
誌名: | 泌尿器科紀要 |
巻: | 25 |
号: | 1 |
開始ページ: | 87 |
終了ページ: | 102 |
抄録: | In order to determine clinical effect of fosfomycin Na(FOM) in urinary tract infections caused by Pseudomonas and Proteus, a comparative study was carried out on patients with chronic complicated urinary tract infections, using sulbenicillin Na(SB-PC) as an active control drug. Both FOM and SB-PC were administered through intravenous infusions in the same dosage of 2 g twice daily for a period of 5 days, and comparisons were made in terms of clinical and bacteriological effects and adverse reactions with a single blind technique. The results obtained were as follows: 1. There was no significant difference in global clinical effects between FOM and SB-PC. 2. With respect to clinical effects as classified by the types of disease, FOM was found to be superior with significant difference in the group of low urinary tract infection. 3. Determinations of MICs of FOM and SB-PC for the isolated organisms revealed higher sensitivity of FOM with significant difference, although no statistically significant difference was seen in terms of disappearance of bacteriuria between the two drugs. 4. There was no significant difference in frequencies of adverse reactions between FOM and SB-PC. All the observed reactions were mild in nature and occurred only in a small number of cases. Therefore, it was concluded that both drugs are of sufficient value to be applied clinically. |
URI: | http://hdl.handle.net/2433/122363 |
出現コレクション: | Vol.25 No.1 |
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