緑膿菌および変形菌による慢性尿路感染症に対するFosfomycin NaとSulbenicillin Naの薬効比較試験

Abstract

In order to determine clinical effect of fosfomycin Na(FOM) in urinary tract infections caused by Pseudomonas and Proteus, a comparative study was carried out on patients with chronic complicated urinary tract infections, using sulbenicillin Na(SB-PC) as an active control drug. Both FOM and SB-PC were administered through intravenous infusions in the same dosage of 2 g twice daily for a period of 5 days, and comparisons were made in terms of clinical and bacteriological effects and adverse reactions with a single blind technique. The results obtained were as follows: 1. There was no significant difference in global clinical effects between FOM and SB-PC. 2. With respect to clinical effects as classified by the types of disease, FOM was found to be superior with significant difference in the group of low urinary tract infection. 3. Determinations of MICs of FOM and SB-PC for the isolated organisms revealed higher sensitivity of FOM with significant difference, although no statistically significant difference was seen in terms of disappearance of bacteriuria between the two drugs. 4. There was no significant difference in frequencies of adverse reactions between FOM and SB-PC. All the observed reactions were mild in nature and occurred only in a small number of cases. Therefore, it was concluded that both drugs are of sufficient value to be applied clinically.