膀胱癌患者における血清蛋白の変動

Abstract

Using a micro-single radial immuncdifusion method, quantitative studies have been made on the serum proteins of bladder cancer patients; 11 patients in the early stage of tumors and 17 patients m the advanced stage. In the early group, 12 proteins (α1AT, α1X, Hp, Cp, IgG, β2III , β２I, IgA, Znα2, C9, C5, βLP) were significantly elevated. In the advanced group, 14 proteins (α1AT, α1AG, α1a, X, Znα2, Hp, Cp, C9, CP3A, C5, β2IIl, C4, βLp, ClsI, IgA) significantly increased and 6 proteins (Pre, Alb, α2HS, α2M, Tf, Pm) significantly decreased. This group showed a significant increase of C9, α1AG and C3PA and a significant decrease of Pre, Alb, α2HS, α2M and Tf as compared with the early stage group. It was assumed that these alterations have a possible usefulness in estimating the stage of tumors or prognosis of disease. There was a significant correlation between C9 andα1AT in all the 28 patients. A possible clinical significance of the alterations of the complement, coagulation, and fibrinolysis systems in cancer patients is mainly discussed.