抗がん剤および抗がん剤投与ラット尿の突然変異誘起性に関する研究(補遺)

Abstract

Several anti-cancer drugs have been reported to be carcinogenic and some of these are suspected of being carcinogenic in man. A high correlation between the mutagenicity and carcinogenicity of anti-cancer drugs has been reported. Therefore, it is very important to determine the presence of mutagens in the urine of patients treated with anti-cancer drugs. There are some problems in the detection of mutagens in human urine in the Salmonella system. Prior to the investigation of human urine, a preliminary experiment was carried out with rats. We have reported that nine of 21 anti-cancer drugs showed the ability to cause mutations in Salmonella typhimurium test strains and the urine from rats treated with six of 7 mutagemic drugs was mutagenic. Six new anti-cancer drugs, ACND, BCND, Ifosphamide, Mithramycin, Natulan and CDDP, were tested. Three drugs, ACND, BCND and CDDP, showed mutagenicity. After six drugs were injected continuously into the juglar veins of rats, urine was collected through a cystostomy tube and tested for mutagenicity. The urine from rats treated with three drugs, BCND, Ifosphamide and CDDP, was mutagenic.