尿由来大腸菌の感受性分布 -外来患者尿由来株と入院患者尿由来株の比較-

Abstract

The present paper reports the isolation and characterization of drug resistant E. coli from the urine from the hospital out-patients and in-patients from 1976 to 1978 December. E. coli strains isolated from urine speciemens during the above period were examinated for sensitivity against 12 drugs such as aminobenzilpenicillin, carbenicillin, minocycline, colistin, nalidixic acid, cephalothin, cephazolin, kanamycin, gentamicin, dibekacin, tobramycin and polymixin. From the urine of out-patients women with acute cystitis, 515 strains of pathogens were isolated during that period, and 388 strains (75.3%) of them were E. coli. From the urine of in-patients, 193 (8.9%) out of 2714 strains isolated from the urine were E. coli. The sensitivity pattern of the above drugs against E. coli from the urine of out-patients showed better sensitivity than that from in-patients. The difference of sensitivity for each drug was smaller in out-patients (from CB-PC 68.8 to GM 100%) than in in-patients (from AB-PC 21.1 to GM 98.4%). Among double drug resistance in out-patients and in-patients, the most frequent combination was AB-PC and CB-PC. In out-patients the multiple drug resistance was within a combination of four drugs, while for in-patients it extended until resistance against all drugs.