男性不妊にかんする内分泌学的研究

Abstract

Hormonal evaluation was made in 228 cases of male infertility (50 cases of azoospermia, 178 cases of oligozoospermia) and the results are as follows: (1) In some patients with sperm count below 10×10/ml, there was an elevation of gonadotropin and/or fall of testosterone. However, there was no hormonal change in those with sperm count greater than 10×10/ml. About half of those with azoospermia including eight of Klinefelter syndrome showed high gonadotropin and/or low testosterone. (2) A normal feedback mechanism was well maintained regardless sperm count or hormonal titers. (3) In patients with azoospermia, testicular response to Clomiphene test was poor, but hypophyseal response to Clomiphene test or LHRH test was nearly equal to that in oligozoospermia. It is assumed that there are some patients with endocrinological abnormality included in those of idiopathic male infertility. Since endocrinological abnormality is testicular origin, these should be differentiated from those of idopathic male infertility group.