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Title: 膀胱癌に対する局所注入療法について 第2報 : OK-432局注療法の効果
Other Titles: TREATMENT OF BLADDER CARCINOMA BY LOCAL INJECTION 2.EVALUfNITION OF OK-432 LOCAL INJECTIONT
Authors: 西尾, 正一  KAKEN_name
井関, 達男  KAKEN_name
仲谷, 達也  KAKEN_name
和田, 誠次  KAKEN_name
堀井, 明範  KAKEN_name
安本, 亮二  KAKEN_name
前川, 正信  KAKEN_name
Author's alias: Nishio, Shoichi
Izeki, Tatsuo
Nakatani, Tatsuya
Wada, Seiji
Horii, Akinori
Yasumoto, Ryoji
Maekawa, Masanobu
Issue Date: Dec-1980
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 26
Issue: 12
Start page: 1485
End page: 1499
Abstract: Nine patients with bladder carcinoma were treated by OK-432 local injection. In 7 out of 9 patients injection was made by transurethral manual and the others were treated by per-cutaneous injection and one was treated by large-dose intra-tumoral injection of OK-432. After local injection of OK-432, endoscopic findings showed white coating of tumor surface and reduction of tumor size. Histological findings showed necrotic change, exfoliation and degeneration of tumor cells or small round cells infiltration. Immunological parameters such as PPD or PHA skin reactions, peripheral lymphocytes counts and PHA-induced blastoid transformation of lymphocytes were compared before and after local injection of OK-432. These reactions might be stronger after local injection in many patients. Especially, PHA skin reaction seemed most useful one as a host resistance among these parameters. As adverse reactions of OK-432 local injection, pyrexia and local pain were shown but these reactions were temporary and well controlled by medication. We discussed about OK-432 local injection against bladder carcinoma as a non-operative treatment.
URI: http://hdl.handle.net/2433/122788
Appears in Collections:Vol.26 No.12

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