膀胱癌に対する局所注入療法について 第2報 : OK-432局注療法の効果

Abstract

Nine patients with bladder carcinoma were treated by OK-432 local injection. In 7 out of 9 patients injection was made by transurethral manual and the others were treated by per-cutaneous injection and one was treated by large-dose intra-tumoral injection of OK-432. After local injection of OK-432, endoscopic findings showed white coating of tumor surface and reduction of tumor size. Histological findings showed necrotic change, exfoliation and degeneration of tumor cells or small round cells infiltration. Immunological parameters such as PPD or PHA skin reactions, peripheral lymphocytes counts and PHA-induced blastoid transformation of lymphocytes were compared before and after local injection of OK-432. These reactions might be stronger after local injection in many patients. Especially, PHA skin reaction seemed most useful one as a host resistance among these parameters. As adverse reactions of OK-432 local injection, pyrexia and local pain were shown but these reactions were temporary and well controlled by medication. We discussed about OK-432 local injection against bladder carcinoma as a non-operative treatment.