ヌードマウス移植ヒト前立腺癌に対する3種制癌剤の抗腫瘍効果およびその生体内動態

Abstract

The growth regressive effect of NK631, MMC and 5FU on human prostatic carcinoma transplanted in nude mice, and their distribution in the tumor, kidney, and skin and subcutaneous tissue were examined. The results were as follows: (1) NK631 showed the growth regressive effect in 15 mg/kg (2 x/w, i.p.) administered group and distributed in the kidney, tumor and skin and subcutaneous tissue in high concentration. (2) MMC showed the growth regressive effect in 2 mg/kg (1 x/w, i.p.) administered group and distributed in the kidney and tumor in relatively high concentration and in the skin and subcutaneous tissue in low concentration. (3) 5FU showed the growth regressive effect in 30 mg/kg (2 x/w, i.p.) administered group and distributed in the kidney and tumor in high concentration and in the skin and subcutaneous tissue in moderate concentration. (4) In therapeutic experiment of anticancer drug on human tumor transplanted in nude mice, care must be taken at the judgement of the growth regressive effect of the drug which distributes in the skin and subcutaneous tissue in high concentration whenever the tumor was transplanted in subcutaneous tissue.