腎細胞癌に対する抗癌剤動脈内注入療法の検討

Abstract

Since 1977, 16 patients with renal cell carcinoma received intra-arterial infusion chemotherapy. Nine of the tumors were diagnosed to be at stage I, 2 at stage II and 5 at stage IV. For intra-arterial infusion a Teflon catheter was implanted into the abdominal aorta via the A. circumflexa femoris lateralis. After radical or palliative nephrectomy, MMC and 5-FU were infused once or twice a week; this therapy was continued for about one year. One patient with a stage I lesion and 4 patients with stage IV lesions died of cancer within 27 months after nephrectomy. Eleven of the patients who had stage I or II lesions are disease-free from 3 to 37 months after operation. Side effects were recognized in all cases. Myelosuppression and disorder of renal function were the main side effects, but they disappeared soon after cessation of chemotherapy.