複雑性尿路感染症に対するCefotaximeの使用経験

Abstract

The clinical effectiveness of Cefotaxime, a new antibiotic, was studied in 18 cases of complicated urinary tract infection. The drug was given in doses of 2 to 6 g, twice or three times a day by intravenous drip infusion for 3 to 9 days. The results are summarized as follows; 1. As to the overall clinical effectiveness based on the UTI efficacy evaluation standards, the response was excellent in II % (2 out of 18 cases), moderate in 50% (9 cases), and poor in 39% (7 cases). Pyuria was cleared in 22%, decreased in II %, and unchanged in 67%. Bacteriuria was eliminated in 61 % and unchanged in 39% (Table 2). 2. The overall clinical effectiveness for the group without indwelling catheters (group 3) was better than that for the group without indwelling catheters (groups 1 and 5) (Table 3). 3. As to the bacteriological response to Cefotaxime, 25 out of the 35 strains isolated (71%) were eradicated, and 10 (29%) persisted (Table 4). 4. No marked adverse reaction was observed. From the above results, Cefotaxime was suggested to be a useful antibiotic in the treatment of complicated urinary tract infections.