Multiple exposure photography methodによる精子運動の研究 - 各種薬剤の影響 -

Abstract

The effects of various compounds, such as Kallikrein, 17β-estradiol, progesterone, prolactin, L-arginine, caffeine, and Solcoseryl, on sperm motility were studied. These compounds were added to fresh human semen offered by 28 volunteers who had presented with various findings, and the percentage of motile sperm and spermatozoal velocity were evaluated by objective semen analysis with the new multiple exposure photography (MEP) method using a stroboscope for photography and a computer for data analysis. Kallikrein slightly increased the percentage of motile sperm but the difference was not statistically significant. This effect was observed mainly in specimens of good sperm motility, but the mean spermatozoal velocity was not changed. No clear influence on sperm motility was obtained with 17β-estradiol, progesterone, and L-arginine in seminal fluid. Prolactin slightly lowered the percentage of motile sperm, and significantly reduced the mean spermatozoa velocity. These results may suggest that there is a correlation between male infertility and elevation of serum and/or seminal prolactin level. Caffeine significantly increased the percentage of motile sperm, but decreased the mean spermatozoal velocity. These findings seem to be due to the fact that immotile live spermatozoa start to move slowly on the addition of caffeine. Solcoseryl suppressed the sperm movement. These results are compared and discussed with the results of other reports.