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Title: Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia.
Authors: Miyata, Jun  kyouindb  KAKEN_id
Yamada, Makiko
Namiki, Chihiro
Hirao, Kazuyuki
Saze, Teruyasu
Fujiwara, Hironobu  kyouindb  KAKEN_id
Shimizu, Mitsuaki
Kawada, Ryosaku
Fukuyama, Hidenao  KAKEN_id
Sawamoto, Nobukatsu  kyouindb  KAKEN_id
Hayashi, Takuji
Murai, Toshiya  kyouindb  KAKEN_id
Author's alias: 宮田, 淳
Keywords: Corpus callosum
Diffusion tensor imaging
Disconnection hypothesis
Facial emotion perception
Inferior longitudinal fasciculus
Tract-based spatial statistics
Issue Date: Jun-2010
Publisher: Elsevier
Journal title: Schizophrenia research
Volume: 119
Issue: 1-3
Start page: 232
End page: 239
Abstract: BACKGROUND: The pathology of schizophrenia is thought to involve multiple gray and white matter regions. A number of studies have revealed impaired social cognition in schizophrenia. Some evidence suggests an association of this social cognition deficit with gray matter reductions in 'social brain' areas. However, no study has yet revealed the association between social cognition abilities and white matter abnormalities in schizophrenia patients. METHODS: Twenty-six schizophrenia patients and 27 healthy controls underwent the Perception of Affect Task (PAT), which consisted of four subtasks measuring different aspects of emotion attribution. Voxelwise group comparison of white matter fractional anisotropy (FA) was performed using tract-based spatial statistics (TBSS). The relation between impaired social cognition ability and FA reduction was examined in patients for each subtask, using simple regression analysis within brain areas that showed a significant FA reduction in patients compared with controls. The same correlational analysis was also performed for healthy controls in the whole brain. RESULTS: Schizophrenia patients showed reduced emotion attribution ability compared with controls in all four subtasks. The facial emotion perception subtask showed a significant correlation with FA reductions in the left occipital white matter region and left posterior callosal region. The correlational analyses in healthy controls revealed no significant correlation of FA with any of the PAT subtasks. CONCLUSIONS: Our voxelwise correlational analysis of white matter provided a potential neural basis for the social cognition impairments in schizophrenia, in support of the disconnection hypothesis.
Rights: © 2010 Elsevier B.V.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.schres.2009.12.038
PubMed ID: 20097045
Appears in Collections:Journal Articles

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