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Title: Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice.
Authors: Chandana, Ediriweera P S
Maeda, Yasuhiro
Ueda, Akihiko
Kiyonari, Hiroshi
Oshima, Naoko
Yamamoto, Mako  kyouindb  KAKEN_id
Kondo, Shunya
Oh, Junseo
Takahashi, Rei
Yoshida, Yoko  kyouindb  KAKEN_id
Kawashima, Satoshi
Alexander, David B
Kitayama, Hitoshi  kyouindb  KAKEN_id
Takahashi, Chiaki
Tabata, Yasuhiko  kyouindb  KAKEN_id
Matsuzaki, Tomoko  kyouindb  KAKEN_id
Noda, Makoto  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 野田, 亮
Issue Date: 6-Aug-2010
Publisher: BioMed Central Ltd.
Journal title: BMC developmental biology
Volume: 10
Thesis number: 84
Abstract: BACKGROUND: Developmental angiogenesis proceeds through multiple morphogenetic events including sprouting, intussusception, and pruning. Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10.5 with halted vascular development; however, the mechanisms by which this phenotype arises remain unclear. RESULTS: We found that Reck is abundantly expressed in the cells associated with blood vessels undergoing angiogenesis or remodelling in the uteri of pregnant female mice. Some of the Reck-positive vessels show morphological features consistent with non-sprouting angiogenesis. Treatment with a vector expressing a small hairpin RNA against Reck severely disrupts the formation of blood vessels with a compact, round lumen. Similar defects were found in the vasculature of Reck-deficient or Reck conditional knockout embryos. CONCLUSIONS: Our findings implicate Reck in vascular remodeling, possibly through non-sprouting angiogenesis, in both maternal and embyonic tissues.
Rights: © 2010 Chandana et al; licensee BioMed Central Ltd.
DOI(Published Version): 10.1186/1471-213X-10-84
PubMed ID: 20691046
Appears in Collections:Journal Articles

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