ダウンロード数: 357
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.compchemeng.2009.07.002.pdf | 1.2 MB | Adobe PDF | 見る/開く |
タイトル: | A novel multi-dimensional visualization technique for understanding the design parameters of drug formulations |
著者: | Yamashita, Fumiyoshi https://orcid.org/0000-0002-3503-8696 (unconfirmed) Itoh, Takayuki Yoshida, Shuya Haidar, Mohammad K. Hashida, Mitsuru |
著者名の別形: | 山下, 富義 |
キーワード: | Design of experiments Response surface method Data visualization Formulation design Design space Nasal drug formulations |
発行日: | 9-Aug-2010 |
出版者: | Elsevier BV |
誌名: | Computers & Chemical Engineering |
巻: | 34 |
号: | 8 |
開始ページ: | 1306 |
終了ページ: | 1311 |
抄録: | The quality-by-design concept is a new regulatory paradigm for pharmaceutical development, while the response surface method (RSM) is a promising approach for understanding design parameters for drug formulations. RSM aims to provide a visual image to support statistical design and analysis of experiments. However, neither contour plots nor 3D surface plots that have commonly been used can completely visualize interactions between the parameters within the design space, due to their limited dimensionality. This article presents a visualization technique that can simultaneously display the responses to multi-dimensional factors by mapping N-dimensional data onto unique x–y coordinates, re-defined by recursive slice-and-dice subdivision of the 2D plane. The applicability of the technique was confirmed using published data on the design of nasal drug formulations. |
著作権等: | © 2009 Elsevier Ltd この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/128765 |
DOI(出版社版): | 10.1016/j.compchemeng.2009.07.002 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。