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Title: Inhibition of fatty acid oxidation activates transforming growth factor-beta in cerebrospinal fluid and decreases spontaneous motor activity.
Authors: Fujikawa, Teppei
Fujita, Ryo
Iwaki, Yoko
Matsumura, Shigenobu  kyouindb  KAKEN_id
Fushiki, Tohru  KAKEN_id
Inoue, Kazuo  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 井上, 和生
Keywords: TGF-beta
Fatty acid oxidation
Issue Date: 5-Oct-2010
Publisher: Elsevier Inc.
Journal title: Physiology & behavior
Volume: 101
Issue: 3
Start page: 370
End page: 375
Abstract: We have previously reported that transforming growth factor (TGF)-beta in the cerebrospinal fluid (CSF) is involved in the mechanism underlying the regulation of spontaneous motor activity (SMA) by the central nervous system after exercise. However, it remained unclear what physiological condition triggers the activation of TGF-beta. We hypothesized that the shortage of energy derived from fatty acid (FA) oxidation observed in the early phase of exercise activated TGF-beta in the CSF. To test this hypothesis, we investigated whether mercaptoacetate (MA), an inhibitor of FA oxidation, could induce an activation of TGF-beta in the CSF and a decrease in SMA. Intraperitoneal (i.p.) administration of MA activated TGF-beta in CSF in rats and depressed SMA; 2-deoxyglucose, an inhibitor of carbohydrate oxidation, on the other hand, depressed SMA but failed to activate CSF TGF-beta. Intracisternal administration of anti-TGF-beta antibody abolished the depressive effect of MA on SMA. We also found that the depression of SMA and the activation of TGF-beta in the CSF by i.p. MA administration were eliminated by vagotomy. Our data suggest that TGF-beta in the CSF is activated by the inhibition of FA oxidation via the vagus nerve and that this subsequently induces depression of SMA.
Rights: © 2010 Elsevier Inc.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.physbeh.2010.06.006
PubMed ID: 20619281
Appears in Collections:Journal Articles

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