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ファイル | 記述 | サイズ | フォーマット | |
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j.mam.2010.06.002.pdf | 518.96 kB | Adobe PDF | 見る/開く |
タイトル: | HTLV-1 bZIP factor gene: Its roles in HTLV-1 pathogenesis. |
著者: | Matsuoka, Masao |
著者名の別形: | 松岡, 雅雄 |
キーワード: | Human T-cell leukemia virus type 1 (HTLV-1) Tax HTLV-1 bZIP factor (HBZ) Leukemogenesis |
発行日: | Oct-2010 |
出版者: | Elsevier Ltd |
誌名: | Molecular aspects of medicine |
巻: | 31 |
号: | 5 |
開始ページ: | 359 |
終了ページ: | 366 |
抄録: | The HTLV-1 bZIP factor (HBZ) gene is transcribed as an anti-sense transcript of HTLV-1 from the 3' long terminal repeat (LTR). Recent studies showed that the HBZ gene was expressed in all ATL cases, suggesting its critical role in leukemogenesis. In addition, only the HBZ gene sequence remains intact, unaffected by nonsense mutations and deletion. HBZ mRNA promotes proliferation of adult T-cell leukemia (ATL) cells. The HBZ protein has three domains: activation, central, and bZIP domains. HBZ interacts with a variety of cellular factors, and modulates not only cellular functions, but also viral gene transcription from 5'LTR. The complex functions of HBZ modulate T-cells, and promote their proliferation, which is likely indispensable for leukemogenesis by HTLV-1. |
著作権等: | © 2010 Elsevier Ltd この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/131803 |
DOI(出版社版): | 10.1016/j.mam.2010.06.002 |
PubMed ID: | 20599553 |
出現コレクション: | 学術雑誌掲載論文等 |
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