Downloads: 329

Files in This Item:
File Description SizeFormat 
j.devcel.2010.08.004.pdf438.61 kBAdobe PDFView/Open
Title: Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity.
Authors: Harumoto, Toshiyuki  kyouindb  KAKEN_id  orcid (unconfirmed)
Ito, Masayoshi
Shimada, Yuko
Kobayashi, Tetsuya J
Ueda, Hiroki R
Lu, Bingwei
Uemura, Tadashi  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 春本, 敏之
上村, 匡
Issue Date: 14-Sep-2010
Publisher: Elsevier B.V.
Journal title: Developmental cell
Volume: 19
Issue: 3
Start page: 389
End page: 401
Abstract: How global organ asymmetry and individual cell polarity are connected to each other is a central question in studying planar cell polarity (PCP). In the Drosophila wing, which develops PCP along its proximal-distal (P-D) axis, we previously proposed that the core PCP mediator Frizzled redistributes distally in a microtubule (MT)-dependent manner. Here, we performed organ-wide analysis of MT dynamics by introducing quantitative in vivo imaging. We observed MTs aligning along the P-D axis at the onset of redistribution and a small but significant excess of + ends-distal MTs in the proximal region of the wing. This characteristic alignment and asymmetry of MT growth was controlled by atypical cadherins Dachsous (Ds) and Fat (Ft). Furthermore, the action of Ft was mediated in part by PAR-1. All these data support the idea that the active reorientation of MT growth adjusts cell polarity along the organ axis.
Rights: © 2010 Elsevier B.V.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.devcel.2010.08.004
PubMed ID: 20817616
Appears in Collections:Journal Articles

Show full item record

Export to RefWorks

Export Format: 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.