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Title: Characterization of FDG-PET images after stereotactic body radiation therapy for lung cancer.
Authors: Matsuo, Yukinori  kyouindb  KAKEN_id  orcid (unconfirmed)
Nakamoto, Yuji  kyouindb  KAKEN_id  orcid (unconfirmed)
Nagata, Yasushi
Shibuya, Keiko
Takayama, Kenji  kyouindb  KAKEN_id
Norihisa, Yoshiki
Narabayashi, Masaru  KAKEN_id
Mizowaki, Takashi  kyouindb  KAKEN_id  orcid (unconfirmed)
Saga, Tsuneo  kyouindb  KAKEN_id  orcid (unconfirmed)
Higashi, Tatsuya
Togashi, Kaori  kyouindb  KAKEN_id
Hiraoka, Masahiro  KAKEN_id
Author's alias: 松尾, 幸憲
Keywords: FDG-PET
Stereotactic body radiation therapy
Lung cancer
Issue Date: Nov-2010
Publisher: Elsevier Ireland
Journal title: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Volume: 97
Issue: 2
Start page: 200
End page: 204
Abstract: BACKGROUND AND PURPOSE: The purpose was to characterize (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) findings after stereotactic body radiation therapy (SBRT) for lung cancer. MATERIALS AND METHODS: This was a retrospective review of 32 FDG-PET scans from 23 patients who underwent SBRT for lung cancer and who showed no evidence of local recurrence. The FDG uptake by lesions was assessed visually using a 3-point scale (0, none or faint; 1, mild; or 2, moderate to intense), and the demarcation (ill- or well-defined) was evaluated. For semi-quantitative analysis, the maximum standardized uptake value (SUVmax) was calculated. RESULTS: Grade 2 intensity was observed in 70%, 33%, 30%, and 0% of PET scans performed <6, 6-12, 12-24, and >24 months, respectively, after SBRT; well-defined demarcation was observed in 80%, 33%, 40%, and 17%, respectively, and the respective means of the SUVmax were 4.9, 2.6, 3.0, and 2.3. The SUVmax was significantly higher for scans performed at <6 months than at 6-12 or >24 months. CONCLUSIONS: FDG uptake tended to be intense and well-defined at early times after SBRT, especially within 6 months, and was faint and ill-defined at later periods. Moderate to intense FDG uptake observed soon after SBRT does not always indicate a residual tumour.
Rights: © 2010 Elsevier Ireland Ltd
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.radonc.2010.04.011
PubMed ID: 20430463
Appears in Collections:Journal Articles

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