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j.micinf.2010.10.001.pdf | 1.35 MB | Adobe PDF | 見る/開く |
タイトル: | Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications. |
著者: | Saito, Akatsuki Nomaguchi, Masako Iijima, Sayuki Kuroishi, Ayumu Yoshida, Tomoyuki Lee, Young-Jung Hayakawa, Toshiyuki Kono, Ken Nakayama, Emi E Shioda, Tatsuo Yasutomi, Yasuhiro Adachi, Akio Matano, Tetsuro Akari, Hirofumi https://orcid.org/0000-0003-2166-6015 (unconfirmed) |
著者名の別形: | 明里, 宏文 |
キーワード: | HIV-1 Old World monkey TRIM5α |
発行日: | Jan-2011 |
出版者: | Elsevier Masson SAS |
誌名: | Microbes and infection / Institut Pasteur |
巻: | 13 |
号: | 1 |
開始ページ: | 58 |
終了ページ: | 64 |
抄録: | Human immunodeficiency virus type 1 (HIV-1) hardly replicates in Old World monkeys. Recently, a mutant HIV-1 clone, NL-DT5R, in which a small part of gag and the entire vif gene are replaced with SIVmac239-derived ones, was shown to be able to replicate in pigtail monkeys but not in rhesus monkeys (RM). In the present study, we found that a modified monkey-tropic HIV-1 (HIV-1mt), MN4-5S, acquired the ability to replicate efficiently in cynomolgus monkeys as compared with the NL-DT5R, while neither NL-DT5R nor MN4-5S replicated in RM cells. These results suggest that multiple determinants may be involved in the restriction of HIV-1 replication in macaques, depending on the species of macaques. The new HIV-1mt clone will be useful for studying molecular mechanisms by which anti-viral host factors regulate HIV-1 replication in macaques. |
著作権等: | © 2010 Institut Pasteur Published by Elsevier Masson SAS この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/134587 |
DOI(出版社版): | 10.1016/j.micinf.2010.10.001 |
PubMed ID: | 20955815 |
出現コレクション: | 学術雑誌掲載論文等 |
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