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タイトル: Enhanced Intracellular Delivery Using Arginine-Rich Peptides by the Addition of Penetration Accelerating Sequences (Pas)
著者: Takayama, Kentaro
Nakase, Ikuhiko
Michiue, Hiroyuki
Takeuchi, Toshihide  KAKEN_id
Tomizawa, Kazuhito
Matsui, Hideki
Futaki, Shiroh  orcid https://orcid.org/0000-0002-0124-4002 (unconfirmed)
著者名の別形: 髙山, 健太郎
キーワード: arginine-rich peptide
cell penetrating peptide
intracellular delivery
p53 C-terminal segment
retro-inverso peptide
発行日: 1-Sep-2009
出版者: Elsevier Inc
誌名: Journal of Controlled Release
巻: 138
号: 2
開始ページ: 128
終了ページ: 133
抄録: Cell penetrating peptides (CPPs), including arginine-rich peptides, are attractive tools for the intracellular delivery of various bioactive molecules with a low membrane permeability. We showed that the accelerated intracellular delivery of arginine-rich peptides was achieved by the addition of a short peptide segment (penetration accelerating sequence, Pas) to arginine-rich CPPs. The cytosolic release of the Pas-attached arginine-rich CPPs was observed within 5 min after the treatment of the cells with the peptides even in the presence of serum. Effectiveness of the Pas segment in the intracellular delivery of bioactive peptides using arginine-rich CPPs was exemplified through the enhanced growth inhibition activity of the malignant glioma cells by a retro-inverso peptide derived from the p53 C-terminal 22-amino-acid segment (positions 361-382).
著作権等: © 2009 Elsevier Inc.
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/134604
DOI(出版社版): 10.1016/j.jconrel.2009.05.019
PubMed ID: 19465072
出現コレクション:学術雑誌掲載論文等

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