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タイトル: | Enhanced Intracellular Delivery Using Arginine-Rich Peptides by the Addition of Penetration Accelerating Sequences (Pas) |
著者: | Takayama, Kentaro Nakase, Ikuhiko Michiue, Hiroyuki Takeuchi, Toshihide Tomizawa, Kazuhito Matsui, Hideki Futaki, Shiroh https://orcid.org/0000-0002-0124-4002 (unconfirmed) |
著者名の別形: | 髙山, 健太郎 |
キーワード: | arginine-rich peptide cell penetrating peptide intracellular delivery p53 C-terminal segment retro-inverso peptide |
発行日: | 1-Sep-2009 |
出版者: | Elsevier Inc |
誌名: | Journal of Controlled Release |
巻: | 138 |
号: | 2 |
開始ページ: | 128 |
終了ページ: | 133 |
抄録: | Cell penetrating peptides (CPPs), including arginine-rich peptides, are attractive tools for the intracellular delivery of various bioactive molecules with a low membrane permeability. We showed that the accelerated intracellular delivery of arginine-rich peptides was achieved by the addition of a short peptide segment (penetration accelerating sequence, Pas) to arginine-rich CPPs. The cytosolic release of the Pas-attached arginine-rich CPPs was observed within 5 min after the treatment of the cells with the peptides even in the presence of serum. Effectiveness of the Pas segment in the intracellular delivery of bioactive peptides using arginine-rich CPPs was exemplified through the enhanced growth inhibition activity of the malignant glioma cells by a retro-inverso peptide derived from the p53 C-terminal 22-amino-acid segment (positions 361-382). |
著作権等: | © 2009 Elsevier Inc. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/134604 |
DOI(出版社版): | 10.1016/j.jconrel.2009.05.019 |
PubMed ID: | 19465072 |
出現コレクション: | 学術雑誌掲載論文等 |
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