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Title: Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin.
Authors: Sato, Shin-Ichi  kyouindb  KAKEN_id
Murata, Asako
Orihara, Tsubasa
Shirakawa, Takashi
Suenaga, Kiyotake
Kigoshi, Hideo
Uesugi, Motonari  kyouindb  KAKEN_id  orcid (unconfirmed)
Author's alias: 上杉, 志成
Issue Date: 28-Jan-2011
Publisher: Elsevier Ltd
Journal title: Chemistry & biology
Volume: 18
Issue: 1
Start page: 131
End page: 139
Abstract: Aurilide is a potent cytotoxic marine natural product that induces apoptosis in cultured human cells at the picomolar to nanomolar range; however, its mechanism of action has been unknown. Results of the present study showed that aurilide selectively binds to prohibitin 1 (PHB1) in the mitochondria, activating the proteolytic processing of optic atrophy 1 (OPA1) and resulting in mitochondria-induced apoptosis. The mechanism of aurilide cytotoxicity suggests that PHB1 is an apoptosis-regulating protein amenable to modulation by small molecules. Aurilide may serve as a small-molecule tool for studies of mitochondria-induced apoptosis.
Rights: © 2011 Elsevier Ltd
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.chembiol.2010.10.017
PubMed ID: 21276946
Appears in Collections:Journal Articles

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