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|j.chembiol.2010.10.017.pdf||711.99 kB||Adobe PDF||View/Open|
|Title:||Marine Natural Product Aurilide Activates the OPA1-Mediated Apoptosis by Binding to Prohibitin.|
|Authors:||Sato, Shin-Ichi |
Uesugi, Motonari https://orcid.org/0000-0002-8515-445X (unconfirmed)
|Author's alias:||上杉, 志成|
|Journal title:||Chemistry & biology|
|Abstract:||Aurilide is a potent cytotoxic marine natural product that induces apoptosis in cultured human cells at the picomolar to nanomolar range; however, its mechanism of action has been unknown. Results of the present study showed that aurilide selectively binds to prohibitin 1 (PHB1) in the mitochondria, activating the proteolytic processing of optic atrophy 1 (OPA1) and resulting in mitochondria-induced apoptosis. The mechanism of aurilide cytotoxicity suggests that PHB1 is an apoptosis-regulating protein amenable to modulation by small molecules. Aurilide may serve as a small-molecule tool for studies of mitochondria-induced apoptosis.|
|Rights:||© 2011 Elsevier Ltd|
This is not the published version. Please cite only the published version.
|Appears in Collections:||Journal Articles|
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