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タイトル: The Influence of Chronic Cerebral Hypoperfusion on Cognitive Function and Amyloid β Metabolism in APP Overexpressing Mice.
著者: Yamada, Mahito
Ihara, Masafumi
Okamoto, Yoko
Maki, Takakuni  kyouindb  KAKEN_id
Washida, Kazuo
Kitamura, Akihiro
Hase, Yoshiki
Ito, Hidefumi
Takao, Keizo
Miyakawa, Tsuyoshi
Kalaria, Raj N
Tomimoto, Hidekazu
Takahashi, Ryosuke  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-1407-9640 (unconfirmed)
著者名の別形: 猪原, 匡史
発行日: 2011
出版者: Public Library of Science(PLoS)
誌名: PloS one
巻: 6
号: 1
論文番号: e16567
抄録: Cognitive impairment resulting from cerebrovascular insufficiency has been termed vascular cognitive impairment, and is generally accepted to be distinct from Alzheimer's disease resulting from a neurodegenerative process. However, it is clear that this simple dichotomy may need revision in light of the apparent occurrence of several shared features between Alzheimer's disease and vascular cognitive impairment. Nevertheless, it still remains largely unknown whether the burden of vascular- and Alzheimer-type neuropathology are independent or interdependent. Therefore, we investigated whether chronic cerebral hypoperfusion influences cognitive ability or amyloid β deposition in amyloid precursor protein (APP) overexpressing transgenic mice.
著作権等: © 2011 Yamada et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/138083
DOI(出版社版): 10.1371/journal.pone.0016567
PubMed ID: 21305033
出現コレクション:学術雑誌掲載論文等

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