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タイトル: | The Influence of Chronic Cerebral Hypoperfusion on Cognitive Function and Amyloid β Metabolism in APP Overexpressing Mice. |
著者: | Yamada, Mahito Ihara, Masafumi Okamoto, Yoko Maki, Takakuni Washida, Kazuo Kitamura, Akihiro Hase, Yoshiki Ito, Hidefumi Takao, Keizo Miyakawa, Tsuyoshi Kalaria, Raj N Tomimoto, Hidekazu Takahashi, Ryosuke https://orcid.org/0000-0002-1407-9640 (unconfirmed) |
著者名の別形: | 猪原, 匡史 |
発行日: | 2011 |
出版者: | Public Library of Science(PLoS) |
誌名: | PloS one |
巻: | 6 |
号: | 1 |
論文番号: | e16567 |
抄録: | Cognitive impairment resulting from cerebrovascular insufficiency has been termed vascular cognitive impairment, and is generally accepted to be distinct from Alzheimer's disease resulting from a neurodegenerative process. However, it is clear that this simple dichotomy may need revision in light of the apparent occurrence of several shared features between Alzheimer's disease and vascular cognitive impairment. Nevertheless, it still remains largely unknown whether the burden of vascular- and Alzheimer-type neuropathology are independent or interdependent. Therefore, we investigated whether chronic cerebral hypoperfusion influences cognitive ability or amyloid β deposition in amyloid precursor protein (APP) overexpressing transgenic mice. |
著作権等: | © 2011 Yamada et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/138083 |
DOI(出版社版): | 10.1371/journal.pone.0016567 |
PubMed ID: | 21305033 |
出現コレクション: | 学術雑誌掲載論文等 |
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