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journal.pone.0016567.pdf | 587.52 kB | Adobe PDF | 見る/開く |
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dc.contributor.author | Yamada, Mahito | en |
dc.contributor.author | Ihara, Masafumi | en |
dc.contributor.author | Okamoto, Yoko | en |
dc.contributor.author | Maki, Takakuni | en |
dc.contributor.author | Washida, Kazuo | en |
dc.contributor.author | Kitamura, Akihiro | en |
dc.contributor.author | Hase, Yoshiki | en |
dc.contributor.author | Ito, Hidefumi | en |
dc.contributor.author | Takao, Keizo | en |
dc.contributor.author | Miyakawa, Tsuyoshi | en |
dc.contributor.author | Kalaria, Raj N | en |
dc.contributor.author | Tomimoto, Hidekazu | en |
dc.contributor.author | Takahashi, Ryosuke | en |
dc.contributor.alternative | 猪原, 匡史 | ja |
dc.date.accessioned | 2011-03-04T05:11:51Z | - |
dc.date.available | 2011-03-04T05:11:51Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2433/138083 | - |
dc.description.abstract | Cognitive impairment resulting from cerebrovascular insufficiency has been termed vascular cognitive impairment, and is generally accepted to be distinct from Alzheimer's disease resulting from a neurodegenerative process. However, it is clear that this simple dichotomy may need revision in light of the apparent occurrence of several shared features between Alzheimer's disease and vascular cognitive impairment. Nevertheless, it still remains largely unknown whether the burden of vascular- and Alzheimer-type neuropathology are independent or interdependent. Therefore, we investigated whether chronic cerebral hypoperfusion influences cognitive ability or amyloid β deposition in amyloid precursor protein (APP) overexpressing transgenic mice. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science(PLoS) | en |
dc.rights | © 2011 Yamada et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.title | The Influence of Chronic Cerebral Hypoperfusion on Cognitive Function and Amyloid β Metabolism in APP Overexpressing Mice. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | PloS one | en |
dc.identifier.volume | 6 | - |
dc.identifier.issue | 1 | - |
dc.relation.doi | 10.1371/journal.pone.0016567 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | e16567 | - |
dc.identifier.pmid | 21305033 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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