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Title: A more efficient method to generate integration-free human iPS cells.
Authors: Okita, Keisuke  kyouindb  KAKEN_id  orcid (unconfirmed)
Matsumura, Yasuko
Sato, Yoshiko
Okada, Aki
Morizane, Asuka  kyouindb  KAKEN_id  orcid (unconfirmed)
Okamoto, Satoshi
Hong, Hyenjong
Nakagawa, Masato  kyouindb  KAKEN_id  orcid (unconfirmed)
Tanabe, Koji
Tezuka, Ken-Ichi
Shibata, Toshiyuki
Kunisada, Takahiro
Takahashi, Masayo
Takahashi, Jun  kyouindb  KAKEN_id
Saji, Hiroh
Yamanaka, Shinya  kyouindb  KAKEN_id
Author's alias: 沖田, 圭介
山中, 伸弥
Issue Date: 3-Apr-2011
Publisher: Nature Publishing Group
Citation: Okita K, Matsumura Y, Sato Y, Okada A, Morizane A, Okamoto S, Hong H, Nakagawa M, Tanabe K, Tezuka KI, Shibata T, Kunisada T, Takahashi M, Takahashi J, Saji H, Yamanaka S. A more efficient method to generate integration-free human iPS cells.Nat Methods. 2011 Apr 3
Journal title: Nature methods
Volume: 8
Start page: 409
End page: 412
Abstract: We report a simple method, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors. We generated human iPSCs from multiple donors, including two putative human leukocyte antigen (HLA)-homozygous donors who match ∼20% of the Japanese population at major HLA loci; most iPSCs are integrated transgene-free. This method may provide iPSCs suitable for autologous and allologous stem-cell therapy in the future.
Description: 遺伝子挿入のないヒトiPS細胞のより簡便な樹立法の開発.京都大学プレスリリース. 2011-04-05.
Rights: © 2011 Nature America, Inc. All rights reserved.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1038/nmeth.1591
PubMed ID: 21460823
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