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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| journal.pone.0019799.pdf | 527.4 kB | Adobe PDF | 見る/開く |
| タイトル: | Dysregulation of IFN system can lead to poor response to pegylated interferon and ribavirin therapy in chronic hepatitis C. |
| 著者: | Onomoto, Koji Morimoto, Shiho Kawaguchi, Takahisa Toyoda, Hidenori Tanaka, Masami Kuroda, Masahiko Uno, Kazuko Kumada, Takashi Matsuda, Fumihiko   Shimotohno, Kunitada Fujita, Takashi Murakami, Yoshiki |
| 著者名の別形: | 村上, 善基 |
| 発行日: | 2011 |
| 出版者: | Public Library of Science |
| 誌名: | PloS one |
| 巻: | 6 |
| 号: | 5 |
| 論文番号: | e19799 |
| 抄録: | Despite being expensive, the standard combination of pegylated interferon (Peg-IFN)- α and ribavirin used to treat chronic hepatitis C (CH) results in a moderate clearance rate and a plethora of side effects. This makes it necessary to predict patient outcome so as to improve the accuracy of treatment. Although the antiviral mechanism of genetically altered IL28B is unknown, IL28B polymorphism is considered a good predictor of IFN combination treatment outcome. |
| 著作権等: | © 2011 Onomoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| URI: | http://hdl.handle.net/2433/141816 |
| DOI(出版社版): | 10.1371/journal.pone.0019799 |
| PubMed ID: | 21603632 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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