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DCフィールド | 値 | 言語 |
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dc.contributor.author | Stanlie, Andre | en |
dc.contributor.author | Aida, Masatoshi | en |
dc.contributor.author | Muramatsu, Masamichi | en |
dc.contributor.author | Honjo, Tasuku | en |
dc.contributor.author | Begum, Nasim A | en |
dc.contributor.alternative | 本庶, 佑 | ja |
dc.date.accessioned | 2011-07-06T05:20:00Z | - |
dc.date.available | 2011-07-06T05:20:00Z | - |
dc.date.issued | 2010-12 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/2433/141990 | - |
dc.description.abstract | Ig class switch recombination (CSR) requires expression of activation-induced cytidine deaminase (AID) and transcription through target switch (S) regions. Here we show that knockdown of the histone chaperone facilitates chromatin transcription (FACT) completely inhibited S region cleavage and CSR in IgA-switch-inducible CH12F3-2A B cells. FACT knockdown did not reduce AID or S region transcripts but did decrease histone3 lysine4 trimethylation (H3K4me3) at both the Sμ and Sα regions. Because knockdown of FACT or H3K4 methyltransferase cofactors inhibited DNA cleavage in H3K4me3-depleted S regions, H3K4me3 may serve as a mark for recruiting CSR recombinase. These findings revealed an unexpected evolutionary conservation between CSR and meiotic recombination. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | National Academy of Sciences | en |
dc.rights | ©2010 by the National Academy of Sciences | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | B-Lymphocytes/metabolism | en |
dc.subject.mesh | Cell Line | en |
dc.subject.mesh | Chromatin/genetics | en |
dc.subject.mesh | Chromatin/metabolism | en |
dc.subject.mesh | Cytidine Deaminase/genetics | en |
dc.subject.mesh | Cytidine Deaminase/metabolism | en |
dc.subject.mesh | DNA/genetics | en |
dc.subject.mesh | DNA/metabolism | en |
dc.subject.mesh | DNA-Binding Proteins/genetics | en |
dc.subject.mesh | DNA-Binding Proteins/metabolism | en |
dc.subject.mesh | Evolution, Molecular | en |
dc.subject.mesh | High Mobility Group Proteins/genetics | en |
dc.subject.mesh | High Mobility Group Proteins/metabolism | en |
dc.subject.mesh | Histones/genetics | en |
dc.subject.mesh | Histones/metabolism | en |
dc.subject.mesh | Immunoglobulin Class Switching/physiology | en |
dc.subject.mesh | Lysine/genetics | en |
dc.subject.mesh | Lysine/metabolism | en |
dc.subject.mesh | Meiosis/physiology | en |
dc.subject.mesh | Methylation | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Transcription, Genetic/physiology | en |
dc.subject.mesh | VDJ Recombinases/genetics | en |
dc.subject.mesh | VDJ Recombinases/metabolism | en |
dc.title | Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00786025 | - |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.identifier.volume | 107 | - |
dc.identifier.issue | 51 | - |
dc.identifier.spage | 22190 | - |
dc.identifier.epage | 22195 | - |
dc.relation.doi | 10.1073/pnas.1016923108 | - |
dc.textversion | author | - |
dc.identifier.pmid | 21139053 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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