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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| journal.pone.0020427.pdf | 2.18 MB | Adobe PDF | 見る/開く |
| タイトル: | Colocalization of 14-3-3 Proteins with SOD1 in Lewy Body-Like Hyaline Inclusions in Familial Amyotrophic Lateral Sclerosis Cases and the Animal Model. |
| 著者: | Okamoto, Yoko Shirakashi, Yoshitomo Ihara, Masafumi Urushitani, Makoto Oono, Miki Kawamoto, Yasuhiro Yamashita, Hirofumi  Shimohama, Shun Kato, Shinsuke Hirano, Asao Tomimoto, Hidekazu Ito, Hidefumi Takahashi, Ryosuke   https://orcid.org/0000-0002-1407-9640 (unconfirmed) |
| 著者名の別形: | 猪原, 匡史 |
| 発行日: | May-2011 |
| 出版者: | Public Library of Science |
| 誌名: | PloS one |
| 巻: | 6 |
| 号: | 5 |
| 論文番号: | e20427 |
| 抄録: | Cu/Zn superoxide dismutase (SOD1) is a major component of Lewy body-like hyaline inclusion (LBHI) found in the postmortem tissue of SOD1-linked familial amyotrophic lateral sclerosis (FALS) patients. In our recent studies, 14-3-3 proteins have been found in the ubiquitinated inclusions inside the anterior horn cells of spinal cords with sporadic amyotrophic lateral sclerosis (ALS). To further investigate the role of 14-3-3 proteins in ALS, we performed immunohistochemical analysis of 14-3-3 proteins and compared their distributions with those of SOD1 in FALS patients and SOD1-overexpressing mice. |
| 著作権等: | © 2011 Okamoto et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| URI: | http://hdl.handle.net/2433/141995 |
| DOI(出版社版): | 10.1371/journal.pone.0020427 |
| PubMed ID: | 21655264 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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