ダウンロード数: 605
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
s00280-010-1443-5.pdf | 128.94 kB | Adobe PDF | 見る/開く |
タイトル: | A multi-institution phase II study of gemcitabine/S-1 combination chemotherapy for patients with advanced biliary tract cancer. |
著者: | Kanai, Masashi Yoshimura, Kenichi Tsumura, Takehiko Asada, Masanori Suzuki, Chihiro Niimi, Miyuki Matsumoto, Shigemi https://orcid.org/0000-0001-6453-7489 (unconfirmed) Nishimura, Takafumi Nitta, Takashi Yasuchika, Kentaro Taura, Kojiro Mori, Yukiko Hamada, Akihiko Inoue, Naoya Tada, Shinsuke Yanagihara, Kazuhiro Yazumi, Shujiro Osaki, Yukio Chiba, Tsutomu Ikai, Iwao Fukushima, Masanori Uemoto, Shinji Hatano, Etsuro |
著者名の別形: | 金井, 雅史 |
キーワード: | Biliary tract cancer Gemcitabine S-1 Chemotherapy |
発行日: | Jun-2011 |
出版者: | Springer-Verlag |
誌名: | Cancer chemotherapy and pharmacology |
巻: | 67 |
号: | 6 |
開始ページ: | 1429 |
終了ページ: | 1434 |
抄録: | Purpose:We aimed to evaluate the efficacy and safety of gemcitabine/S-1 combination chemotherapy for the treatment of patients with advanced biliary tract cancer. Methods:Patients with histologically or cytologically confirmed unresectable or recurrent biliary tract cancer were eligible for inclusion. The primary endpoint was overall survival. Gemcitabine was administered intravenously at a dose of 1, 000 mg/m2 over 30 min on days 1 and 8, and oral S-1 was administered daily at a dose of 60 mg/m2 on days 1–14. This schedule was repeated every 3 weeks until disease progression or patient refusal. Results:Twenty-five patients were enrolled between October 2007 and January 2009. Eleven patients (44%) had extrahepatic bile duct cancer, 5 (20%) had intrahepatic bile duct cancer, 8 had gallbladder cancer (32%), and 1 (4%) had ampulla of Vater cancer. The median overall survival time was 12.7 months (95% CI, 8.4–23.5 months), and the 1-year survival rate was 52.0% (95% CI, 31.2–69.2%). Of the 23 patients with evaluable target regions, seven patients experienced a partial response, and an overall response rate was 30.4%. The following grade 3–4 hematological toxicities occurred: neutropenia (56%), leukopenia (24%), anemia (8%) and thrombocytopenia (4%). In spite of the high incidence of grade 3–4 neutropenia, no patients developed febrile neutropenia in the present study. The major grade 3–4 non-hematological toxicities were fatigue (8%), anorexia (8%) and diarrhea (4%). Conclusions:Gemcitabine/S-1 combination chemotherapy offered a promising survival benefit with acceptable toxicity in patients with advanced biliary tract cancer. |
著作権等: | The final publication is available at www.springerlink.com This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/143579 |
DOI(出版社版): | 10.1007/s00280-010-1443-5 |
PubMed ID: | 20811895 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。