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Title: The potential clinical value of FDG-PET for recurrent renal cell carcinoma.
Authors: Nakatani, Koya
Nakamoto, Yuji  kyouindb  KAKEN_id  orcid (unconfirmed)
Saga, Tsuneo  kyouindb  KAKEN_id  orcid (unconfirmed)
Higashi, Tatsuya
Togashi, Kaori  kyouindb  KAKEN_id
Author's alias: 中谷, 航也
Keywords: 18F-FDG-PET
Renal cell carcinoma
Prognostic value
Issue Date: Jul-2011
Publisher: Elsevier Ireland Ltd.
Journal title: European journal of radiology
Volume: 79
Issue: 1
Start page: 29
End page: 35
Abstract: Purpose:The clinical value of positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) for follow-up or suspected recurrence of renal cell carcinoma (RCC) has not been fully evaluated. The purpose of this study was to assess the diagnostic performance of FDG-PET for postoperative assessment in patients with RCC. Methods:We reviewed 28 scans in 23 patients who had undergone FDG-PET scans after surgery for RCC. Diagnostic accuracy of visually interpreted PET was evaluated based on final diagnoses obtained histologically or by clinical follow-up at least 6 months. Also, additional information over CT, influence on treatment decisions, and the accuracy of FDG uptake as a predictor of survival were assessed. Results:Recurrence of renal carcinoma was histologically (n = 15) or clinically (n = 6) confirmed in 21 of 28 cases. Overall, the sensitivity, specificity, and diagnostic accuracy using FDG-PET were 81%, 71%, and 79%, respectively. In papillary RCC, the sensitivity was 100%; however, that was 75% in clear cell RCC in patient-basis. PET correctly detected local recurrence and metastases in all cases in the peritoneum, bone, muscle and adrenal gland. Additional information was obtained from scans in 6 cases (21%), which influenced therapeutic management in 3 cases (11%). Cumulative survival rates over 5 years in the PET-positive vs. the PET-negative group were 46% vs. 83%, respectively (p = 0.17). Conclusions:FDG-PET would be useful for postoperative surveillance in patients with RCC, although its impact on treatment decisions may be limited. Further investigations are necessary to conclude whether PET has a prognostic value.
Rights: © 2009 Elsevier Ireland Ltd.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.ejrad.2009.11.019
PubMed ID: 20015602
Appears in Collections:Journal Articles

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